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About
Associate Professor Ian Trounce
Head of Mitochondria and Neurodegeneration
Associate Professor Ian Trounce investigates mitochondria in neurodegenerative diseases, including diseases of the optic nerve.
Associate Professor Ian Trounce
Head of Mitochondria and Neurodegeneration
BSc, PhD
Associate Professor Ian Trounce is Principal Investigator and Head of Mitochondria and Neurodegeneration research at CERA.
Following his PhD studies at the University of Melbourne, he undertook postdoctoral training in the laboratory of Doug Wallace at Emory University before returning to Australia to establish his own laboratory.
His research focus is on mitochondria and how defects in oxidative phosphorylation contribute to age-related neurodegenerative diseases, including diseases of the optic nerve. His expertise encompasses biochemical, molecular and cell biology and genetic approaches.
CERA’s Glaucoma Research focuses on molecular pathogenesis and neuroprotection of the optic nerve in glaucoma. A/Prof Trounce supervises a research team investigating the cellular processes related to ageing and mitochondrial dysfunction that affect the vulnerability of retinal ganglion cells to injury.
This work is intended to develop new therapeutic approaches for protecting the optic nerve in glaucoma. His research scope extends to other neurodegenerative diseases where mitochondrial dysfunction is strongly implicated, especially Parkinson’s disease.
Key research questions
- Does a ‘mismatching’ of mitochondrial DNA and nuclear gene variants contribute to age-related diseases such as glaucoma and Parkinson’s disease?
Current projects
Selected publications
Key collaborators
Funding and support
Current projects
Nuclear-mitochondrial genetics in glaucoma and Parkinson’s disease
Investigating if nuclear gene variants can combine with mitochondrial DNA variants to increase disease risk.
Selected publications
Singh LN, Crowston JG, Lopez Sanchez MIG, Van Bergen NJ, Kearns LS, Hewitt AW, Yazar S, Mackey DA, Wallace DC, Trounce IA. Mitochondrial DNA variation and disease susceptibility in primary open-angle glaucoma. Invest Ophthalmol Vis Sci (2018) 59:4598-4602. DOI: 10.1167/iovs.18-25085
Lopez Sanchez MIG, Crowston JG, Mackey DA, Trounce IA. Emerging therapeutic targets in mitochondrial optic neuropathies. Pharmacology and Therapeutics (2016) 165:132-152. DOI: 10.1016/j.pharmthera.2016.06.004
Crowston J, Trounce I. Relief for retinal neurons under pressure. Science (2017) 355:688-9. DOI: 10.1126/science.aam7935
Van Bergen NJ, Crowston JG, Craig JE, Burdon KP, LS Kearns, Sharma S, Hewitt AW, Mackey DA, Trounce IA. Measurement of systemic mitochondrial function in advanced Primary Open-Angle Glaucoma and Leber Hereditary Optic Neuropathy. Plos One (2015) 10(10):e0140919. DOI: 10.1371/journal.pone.0140919
See more publications
Key collaborators
- Isabel Lopez Sanchez, CERA
- Jonathan Crowston, Duke University Singapore
- Doug Wallace, University of Pennsylvania
- Dan Mishmar, Ben Gurion University Israel
- Justin StJohn, University of Adelaide
Funding and support
Thank you to the following organisations for their support:
- NHMRC
- Kathleen Rankin Bequest
- Michelmore Foundation
- DHB Foundation
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