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About
Professor Chi Luu
Principal Research Fellow
Professor Chi Luu is a clinician scientist with a research focus on disease pathophysiology, neural modulation, therapeutic stimulation, preclinical safety and efficacy evaluation of novel therapies, and developing vision restoration strategies for retinal degenerative conditions.
Professor Chi Luu
Principal Research Fellow
BOrth(Hons), GradDip(Epi&Biostats), PhD, FARVO
Professor Chi Luu is a Principal Research Fellow at the Centre for Eye Research Australia (CERA) and Hong Leong Professor of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore.
His research interests include inherited retinal disease (IRD), age-related macular degeneration (AMD) and vision restoration approaches for blinding retinal conditions. He conducts both preclinical and clinical studies to better understand the pathophysiology of disease, and to evaluate safety and efficacy of novel interventions.
Professor Luu’s expertise includes retinal and cortical electrophysiology, visual psychophysics (dark-adaptation and scotopic chromatic perimetry), retinal imaging and microsurgery for device implantation and delivering drugs to the retina by microinjection technique in preclinical models.
In recognition of his contributions to eye research, he has been elected as a member of the Macula Society and awarded Fellow of the Association for Research in Vision and Ophthalmology (FARVO).
Key research questions
- What is the role of retinal blood flow regulation in the development and progression of age-related macular degeneration?
- What is the most effective way to extend the visual life of patients with blinding eye conditions?
- How to improve the resolution of a bionic eye (retinal prosthesis)?
- How can we use cellular reprogramming and gene therapy to develop new treatments for retinal diseases?
Current projects
Selected publications
Key collaborators
Funding and support
Current projects
- Pathophysiology of IRD and AMD.
- Preclinical safety and efficacy studies of novel interventions for inherited retinal diseases.
- Investigating ways to retain and restore vision from retinal degenerative conditions using electrotherapeutic approach (retinal prosthesis and neuroprotective stimulation).
- Novel methods to deliver drugs to the retina.
- Using cellular reprogramming technology to restore vision from inherited blinding eye conditions (in collaboration with Associate Professor Raymond Wong, CERA).
- Using gene therapy for treating retinal neovascular and degenerative conditions (in collaboration with Associate Professor Guei-Sheung (Rick) Liu, CERA).
- Developing and evaluating clinical tools for monitoring disease progression in RP (in collaboration with Professor Lauren Ayton and Dr Ceecee Britten-Jones, University of Melbourne).
- Improving retinal health with medicinal plants (in collaboration with Associate Professor Tien Huynh, RMIT).
- Neurovascular coupling in human retina (in collaboration with Dr Luis Alarcon-Martinez and Dr Anna Wang, CERA).
Selected publications
Britten-Jones AC, Luu CD, Jolly JK, Abbott CJ, Allen PJ, Lamey T, McLaren T, Thompson JA, De Roach J, Edwards TL, Ayton LN. Longitudinal Assessment of Structural and Functional Changes in Rod-cone Dystrophy: A 10-year Follow-up Study. Ophthalmology Science 2025;5.
doi: 10.1016/j.xops.2024.100649
Wong WM, Tham YC, Simunovic MP, Chen FK, Luu CD, Chen H, Jin ZB, Shen RJ, Li S, Sui R, Zhao C, Yang L, Bhende M, Raman R, Sen P, Ghosh A, Poornachandra B, Sasongko MB, Arianti A, Chia V, Mangunsong CO, Manurung F, Fujinami K, Ikeda H, Woo SJ, Kim SJ, Mohd Khialdin S, Othman O, Bastion MC, Kamalden AT, Lott PWP, Fong K, Shunmugam M, Lim A, Thapa R, Pradhan E, Rajkarnikar SP, Adhikari S, Ibanez B, Koh A, Chan CMM, Fenner BJ, Tan TE, Laude A, Ngo WK, Holder GE, Su X, Chen TC, Wang NK, Kang EY, Huang CH, Surawatsatien N, Pisuchpen P, Sujirakul T, Kumaramanickavel G, Singh M, Leroy B, Michaelides M, Cheng CY, Chen LJ, Chan HW. Rationale and protocol paper for the Asia Pacific Network for inherited eye diseases. Asia Pac J Ophthalmol (Phila) 2024;13:100030.
doi: 10.1016/j.apjo.2023.100030
Bui B, Guymer RH, Heriot W, Metha A, Luu CD. Impairment of Neurovascular Function in Intermediate Age-Related Macular Degeneration. Translational vision science & technology 2024;13.
doi: 10.1167/tvst.13.11.4
Petoe MA, Abbott CJ, Titchener SA, Kolic M, Kentler WG, Nayagam DAX, Baglin EK, Kvansakul J, Barnes N, Walker JG, Karapanos L, McGuinness MB, Ayton LN, Luu CD, Allen PJ, Bionics I, Centre for Eye Research Australia Retinal Prosthesis C. A Second-Generation (44-Channel) Suprachoroidal Retinal Prosthesis: A Single-Arm Clinical Trial of Feasibility. Ophthalmol Sci 2024;5:100525.
doi: 10.1016/j.xops.2024.100525
Abbott CJ, Allen PJ, Williams CE, Williams RA, Epp SB, Burns O, Thomas R, Harrison M, Thien PC, Saunders A, McGowan C, Sloan C, Luu CD, Nayagam DAX. Chronic electrical stimulation with a peripheral suprachoroidal retinal implant: a preclinical safety study of neuroprotective stimulation. Frontiers in Cell and Developmental Biology 2024;12:1422764.
doi: 10.3389/fcell.2024.1422764
Thiele S, Wu Z, Isselmann B, Pfau M, Guymer RH, Luu CD. Natural History of the Relative Ellipsoid Zone Reflectivity in Age-Related Macular Degeneration. Ophthalmol Retina 2022;6:1165-1172.
doi: 10.1016/j.oret.2022.06.001
Guymer RH, Tan RS, Luu CD. Comparison of visual function tests in intermediate age-related macular degeneration. Translational vision science & technology 2021;10:14.
Guymer RH, Wu Z, Hodgson LAB, Caruso E, Brassington KH, Tindill N, Aung KZ, McGuinness MB, Fletcher EL, Chen FK, Chakravarthy U, Arnold JJ, Heriot WJ, Durkin SR, Lek JJ, Harper CA, Wickremasinghe SS, Sandhu SS, Baglin EK, Sharangan P, Braat S, Luu CD. Subthreshold nanosecond laser intervention in age-related macular degeneration: The LEAD randomized controlled clinical trial. Ophthalmology 2019;126:829-838.
doi: 10.1016/j.oret.2016.12.001
Tan R, Guymer RH, Luu CD. Subretinal drusenoid deposits and the loss of rod function in intermediate age-related macular degeneration. Invest Ophthalmol Vis Sci 2018;59:4154-4161.
Fraser RG, Tan R, Ayton LN, Caruso E, Guymer RH, Luu CD. Assessment of retinotopic rod photoreceptor function using a dark-adapted chromatic perimeter in intermediate age-related macular degeneration. Invest Ophthalmol Vis Sci 2016;57:5436-5442.
Ayton LN, Blamey PJ, Guymer RH, Luu CD, Nayagam DA, Sinclair NC, Shivdasani MN, Yeoh J, McCombe MF, Briggs RJ, Opie NL, Villalobos J, Dimitrov PN, Varsamidis M, Petoe MA, McCarthy CD, Walker JG, Barnes N, Burkitt AN, Williams CE, Shepherd RK, Allen PJ. First-in-human trial of a novel suprachoroidal retinal prosthesis. PLoS One 2014;9:e115239.
doi: 10.1371/journal.pone.0115239
Key collaborators
Funding and support
Thank you to the following organisations for their support:
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